ITGAM and neoplasm: In tumor-bearing mice, the expression of miR-17-5p and miR-20a in tumor-associated MDSCs was found to be lower than in Gr1+CD11b+ cells isolated from the spleens of disease-free mice, indicating that tumor-associated factor downregulated the expression of these two microRNAs, which contribute to immune tolerant microenvironment in tumor sites [66].