HLA-C and neoplasm: Considering that G-MDSC derived ROS and peroxynitrite induce the nitration of TCR and result in its altered specific recognition of MHC/antigen epitopes, we hold the idea that it is G-MDSCs, though not as potent as M-MDSCs, that are more likely to perform specific inhibition of T cell response and are of greater meaning in the formation of MDSC-mediated tumor-specific tolerance in microenvironment.