Similar results were obtained with 3,5,3′-triiodo-L-thyronine (T3) (10−9 to 10−7 M) (Figure 1A) In order to examine the effect of thyroid hormone on signal transduction and cell proliferation in ovarian cancer cells, OVCAR-3 cells were treated with different concentrations of thyroid hormones (T3 or T4) for 30 min. The gene discussed is TG; the disease is ovarian cancer.