To demonstrate the thyroid hormone binding site on the ovarian cancer cell surface integrin αvβ3 that plays a role in hormone-induced ERK1/2 activation, experiments were conducted involving shRNA of αv or β3 to reduce the expression of integrin αv or β3, and three αv and two β3 clones were selected for the assay. This evidence concerns the gene MAPK3 and ovarian carcinoma.