ESR1 and breast cancer: We next analyzed the association between TSPYL6 polymorphisms and BC patient clinicopathological features, which included age, age of menarche, BMI, breastfeeding duration, clinical stage, estrogen receptor status, family history of cancer, procreative time, progesterone receptor status, tumor location, tumor size (cm), tumor type, incipient recurrence, presence of lymph node metastasis, age of menopause, and prim parous age.