To investigate the association between the PTX3 gene expression signature and gastric cancer development, we analyzed a public cohort of 151 nonmalignant (n=39) and gastric cancer (n=112) specimens (GSE37023) [28] and observed significantly lower levels of PTX3 in gastric cancer tissues than in nonmalignant tissues (Figure 2A, P <0.005). The gene discussed is PTX3; the disease is gastric cancer.