IL4 and asthma: Asthma is also thought to be induced by TH2 cytokines, and we thus explored the mechanism underlying the therapeutic effect of BK-1361 by assessing the quantitative mRNA expression of several key TH2 cytokines associated with pathogenesis of asthma, including interleukins (IL)-4, IL-5, IL-13, chemokine (C-C motif) ligand (CCL)5, CCL11 and CCL22.