More importantly, loss of ADAM8 in ADAM8-knockout mice, whilst showing no effect on the fertility and development of the mice, provides moderate protection from BHR and airway inflammation in ovalbumin (OVA)-induced experimental murine model of asthma, suggesting that transient and specific inhibition of ADAM8 function in vivo might be a potential method for treating asthma without major side effects11, 23. Here, ADAM8 is linked to asthma.