Variants identified in the British–Pakistani adults also include LOF alleles in GJB2, MYO3A and COCH genes, which are known to cause hearing loss in humans.42, 43, 44 Third, there could be a protective or modifier genetic variant present in the British adult, which could render the effect of c.658_659delAA allele of CAPN12.45, 46. This evidence concerns the gene COCH and hearing loss disorder.