YAP1 and Huntington disease: Consistent with the increase in the pS127.YAP level and decreased nuclear YAP in LD cells depleted of AJUBA/LIMD1, cell proliferation decreased, while in HD cells, depletion of AJUBA and LIMD1 did not affect cell proliferation, as determined by BrdU uptake (Fig. 1A; quantified in Fig. 1B).