HFE and neurodegenerative disease: Because of mounting evidence that the presence of HFE mutations may increase risk or alter the course of many neurodegenerative diseases it became important to understand how the HFE protein is functioning to modulate iron transport at the brain but also other physiological barriers (Altamura and Muckenthaler 2009; Loeffler et al. 1995; Zecca et al. 2004).