CTNNB1 and basal cell carcinoma: As to the role of SOX9 in the Wnt/beta-catenin pathway, there seems distinct mechanism were reported; SOX9 negatively regulates Wnt/beta-catenin pathway in chondrocytes differentiation44, while another report showed that SOX9 is activated as a downstream target of Wnt/beta-catenin pathway in the initial step or basal cell carcinoma formation45.