The TFs FLI1 and RUNX1, for example, are causally implicated in disorders of thrombopoiesis: Paris-Trousseau syndrome (OMIM 188025) and familial platelet disorder with predisposition to acute myeloid leukemia (FDP-AML, OMIM 601399), respectively3, 4, 5. Here, RUNX1 is linked to acute myeloid leukemia.