Motifs corresponding to NF-E2, ETS proteins (such as ETS1 and FLI1), FOXP3, and AML/RUNX1 were the most highly represented (Fig. 4a); notably, three of these motifs were also enriched at sites of dynamic chromatin in MKMat (Fig. 2e). This evidence concerns the gene FOXP3 and acute myeloid leukemia.