RUNX1 and Thrombocytopenia: In contrast, the highest percentile of MKMat-selective sites were enriched for sequences that bind NF-E2, ETS-family proteins, and RUNX1/AML (Fig. 2e), corresponding to three TFs - NF-E2, FLI1, and RUNX1 - whose absence arrests MK maturation, leading to thrombocytopenia in vivo3, 11, 16.