Many studies have shown that patients with AD have defective insulin receptor (IR) expression and IR binding, diminished IR substrate‐1 (IRS1) and IR substrate‐2 (IRS2) expression, and increased levels of inactivated serine‐phosphorylated IRS1 (Moloney et al., 2010; Talbot et al., 2012). The gene discussed is INSR; the disease is Alzheimer disease.