With respect to once-daily basal insulin injection regimens in T2D, in 11 treat-to-target clinical trials with neutral protamine Hagedorn (NPH) insulin or insulin glargine, maintaining a mean morning fasting glucose of <110 mg/dL required an average basal insulin dose of >0.6 U/kg [48•]—a dose nearly three times greater than that suggested using our revised formula (∼0.2 U/kg). Here, INS is linked to type 2 diabetes mellitus.