Also, Kaplan–Meier curve stratified by the combined expressions of Cyr-61 and COX-2 demonstrated high expressions of both Cyr-61 and COX-2 showed the shortest survival time of gastric cancer patients, while low expressions of both Cyr-61 and COX-2 showed the longest survival time of gastric cancer patients (p < 0.001, Fig. 3c). This evidence concerns the gene PTGS2 and gastric cancer.