In the present study, we examined the expression of Cyr-61 and COX-2 in 82 gastric cancer specimens and 43 non-tumor gastric mucosa specimens, and the results demonstrated the clinical significance of the expressions of Cyr-61 and COX-2 in determining the clinicopathologic features of gastric cancer and predicting its prognostic value. This evidence concerns the gene PTGS2 and neoplasm.