A recent study identified the ARE-driven genes including NQO1 that are responsible for protecting IMR-32 human neuroblastoma cells from hydrogen peroxide-induced apoptosis [69, 70] Therefore, Nrf2, which mediates transcription of ARE-driven genes, is presumably the driving force behind increasing a cluster of protective genes that play an important role in cellular defense against oxidative/nitrosative stress [73]. Here, NQO1 is linked to neuroblastoma.