Of note, studies in βENaC-Tg mice also demonstrated that genetic or pharmacological inhibition of NE and MMP12 does not prevent dehydration-induced airway mucus plugging in vivo indicating that additional rehydration therapies such as osmolytes [19] or modulators of epithelial ion channels including CFTR, ENaC, or alternative Cl− channels [33] may be required for effective treatment of airway mucus plugging in CF. Here, MMP12 is linked to cystic fibrosis.