Recent studies have shown that ZEB1 acts as an oncogene in invasive and metastatic lung cancer cells, in which ZEB1-induced EMT promotes the loss of epithelial cell polarity and adhesion, induces cytoskeleton remodelling and drives growth, migration, invasion and metastasis5, 6, 7, 8, 9, 10, 11. The gene discussed is ZEB1; the disease is lung cancer.