Although the above observations raised the possibility that ZEB1 may be more related to EMT in lung adenocarcinoma compared with other E-box-binding factors, they also suggested a growth-suppressor role for ZEB1, which contradicts previous reports supporting an oncogenic role of ZEB1 in KRAS-mutated lung cancer5, 6, 7, 8, 9, 10, 11, 12. This evidence concerns the gene KRAS and lung adenocarcinoma.