However, a multivariate analysis demonstrated that lymph node metastasis (HR 2.783, CI 1.425–5.822; P = 0.002), and the positive expression of both Sema4D and PlexinB1 (HR 1.079, CI 1.013–2.868; P = 0.044) were an independent risk factors for worse survival (Table 6). This evidence concerns the gene SEMA4D and metastatic malignant neoplasm in the lymph nodes.