SEMA4D and neoplasm: However, a multivariate analysis demonstrated that the depth of tumor invasion (HR 2.692, CI 1.022–9.317; P = 0.044), lymph node metastasis (HR 2.304, CI 1.138–5.069; P = 0.019), and the positive expression of both Sema4D and PlexinB1 (HR 1.681, CI 1.004–2.819; P = 0.047) were an independent risk factors for worse survival (Table 5).