SEZ6 and Rare pervasive developmental disorder: The Sez6 gene is highly conserved between mice and humans, and sez6 mutations and/or altered expression has been associated with febrile seizures (Yu et al. 2007; Mulley et al. 2011), autism spectrum disorder (Cukier et al. 2014; Mariani et al. 2015), intellectual disability (Gilissen et al. 2014) and childhood-onset schizophrenia (Ambalavanan et al. 2016).