BACE1 and Cognitive impairment: NRG1 heterozygous mice display schizophrenia-like endophenotypes and impaired hippocampal plasticity (Stefansson et al. 2002; O’Tuathaigh et al. 2010), and similar schizophrenia-related endophenotypes are seen in BACE1 KO mice (including impaired pre-pulse inhibition, a greater level of hyperactivity induced by a glutamatergic psychostimulant, cognitive impairments and social recognition deficits; Savonenko et al. 2008).