MAPK8 and neoplasm: These conflicting effects have also been reported by other authors who have found opposing functions of certain proteins involved in tumorigenesis, such as the phosphorylation of JNK and its proliferative and antiproliferative function depending on cell type and its crosstalk with other proteins [33], the involvement of the transcription factor Krüppel-like factor 4 (KLF4) in tumorigenesis as a tissue-specific tumor suppressor or oncogene [34], or the association of pFAK-Y397 both with distant and lymph node metastases as well as improved overall survival in ovarian cancer patients [35].