As a pro-apoptotic protein, Bax plays a pivotal role in the activation of mitochondrial apoptosis in neurons after transient cerebral ischemia39, 40 while Bcl-2 is crucial for reducing neuron apoptosis in cerebral ischemia by maintaining the stabilization mitochondria membrane potential41, 42, 43. This evidence concerns the gene BCL2 and Cerebral ischemia.