Our results confirm that the expression levels of TLR7, TLR9 and constituents of TGF-β signaling, OAZ1 and P-Para were significantly altered in the tumor tissues of Smad3+/− VD-deprived mice compared to the tumor tissues of wild type VD deprived mice tumor tissues (Fig. 3a). This evidence concerns the gene TLR7 and neoplasm.