However, it is possible that resistance to steatosis is consequent to the basal or constitutive alterations in gene-expression already observed in the liver of Aox4−/− animals fed ND. In fact, the top (Insulin signaling:generic cascades) and the 6th (Role of Adiponectin in regulation of metabolism) enriched pathways in Aox4−/− liver are involved in the control of lipid metabolism (Suppl. This evidence concerns the gene INS and steatosis.