Patient P33 (Fig. 3 a), who is clinically stable, showed some anemia events during follow-up, accompanied by proportional increases in RDW values (points 3, 5, 7, 17 and 19 in the x-axis of Fig. 3 a), which then turn to normal values accompanied by normal Hb levels. The gene discussed is GSTM1; the disease is anemia.