IL33 and Alzheimer disease: The implication of Il-33 gene polymorphism in the etiology of AD disease [13, 14] had led to a further investigation [29], which reported that IL-33 and ST2 positive cells were significantly increased in the AD brains when compared with non-AD brains, and the expression was associated with signatures of AD pathology (e.g. amyloid plagues and neurofibrillary tangles).