The specific GLS1 inhibitor bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) inhibits proliferation of lymphoma cells but has no effect on neuroblastoma cells, which express GLS2 [214, 215], implying that the general GLS inhibitor 6-diazo-5-oxo-L-norleucine (DON) may exhibit broader antitumor effects [216, 217]. The gene discussed is GLS; the disease is lymphoma.