Defects in P53 function lead to impaired transactivation of SCO2, a mitochondrial protein required for the correct assembly of the cytochrome c oxidase in the ETC and of TIGAR, an isoform of 6-phospho-fructo-2-kinase, whose expression exerts a tumor suppressor function by inhibiting glycolytic flux [122, 123]. Here, TP53 is linked to neoplasm.