Besides these important roles of NRF2 on detoxification, it has also been shown that NRF2 can contribute to other aspects of cancer survival such as the counteraction of cell death by BCL-2 overexpression [180] and altered metabolism by redirecting glucose and glutamine to the production of ribose-5-phosphate for nucleotide synthesis and to the regeneration of NADPH through the activation of the pentose-phosphate pathway [181]. This evidence concerns the gene BCL2 and cancer.