The results also show that certain foods or food combinations that increase insulin secretion do not reduce blood glucose levels in a dose-dependent manner in healthy or T2DM subjects; this implies that other critical factors, such as the insulin sensitivity, insulin clearance rates, and non-insulin-dependent mechanisms of glucose uptake by muscle and adipose, must also be taken into account when assessing the impact of a food, meal or diet on glycemic response. Here, INS is linked to type 2 diabetes mellitus.