However, the protein-dependent increase in glucagon does not correspond to an increase in blood glucose concentrations in healthy subjects or in subjects with T2DM, likely due to the proteins’ effects on insulin and incretin secretion and, in turn, insulin’s and GLP-1’s ability to suppress glucagon’s effects on gluconeogenesis and glycogenolysis [80,81,82]. The gene discussed is INS; the disease is type 2 diabetes mellitus.