This study was designed to evaluate the effects of two commercially available DSNFs; Glucerna (Abbott Nutrition Inc., Columbus, OH, USA) and Ultra Glucose Control (Metagenics Inc., Aliso Viejo, CA, USA) versus OM (Quaker Oats Co., Chicago, IL, USA) on PP plasma glucose, serum insulin, serum active GLP-1 hormone, serum free fatty acids (FFA) and serum triglycerides (TG) in overweight and obese patients with type 2 diabetes. The gene discussed is INS; the disease is type 2 diabetes mellitus.