Papuamine, a C2-symmetrical pentacyclic alkaloid from the marine sponge Haliclona sp., decreases survival of breast cancer MCF-7 cells, which when treated for four hours with papuamine revealed an increase in LC3 expression, suggesting that it was able to induce early autophagy in MCF-7 cells that later activated c-Jun N-terminal kinase (JNK) [93]. The gene discussed is MAP1LC3A; the disease is breast cancer.