EIF2A and Familial prostate cancer: From marine bacteria Salinispora tropica and Salinispora arenicola has been isolated a potent proteasome inhibitor, the salinosporamide A. This marine natural compound induced autophagy through a phospho-eukaryotic translation initiation factor 2α (eIF2α) pathway so as to reduce proteotoxic stresses in human prostate cancer cells [106].