Representative IHC staining of p-Akt and Snail with different image scores on serial section of the same patients are shown in Figure 2A. IHC analysis of PCa specimens revealed a significant positive correlation between p-Akt and Snail expressions (Spearman correlation coefficient r = 0.851, p < 0.0001; Figure 2B). Here, AKT1 is linked to posterior cortical atrophy.