The concomitant treatment of IGF-1R inhibitors such as α-IR3, AG1024 or R1507 with EGFR-TKIs may enhance TKI-induced growth inhibition and apoptosis, representing a potential strategy for overcoming primary resistance to EGFR-TKIs in NSCLC [29,30]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.