As the β-catenin/Wnt signaling pathway was widely reported in OS and correlated to tumor growth, and several studies revealed that XRCC6 was a regulator of the β-catenin/Wnt signaling pathway [20,21], we examined whether XRCC6 could influence OS cell proliferation by regulating downstream of these pathways using Western blot analysis. This evidence concerns the gene XRCC6 and neoplasm.