There are now some selective MMP inhibitors developed for the treatment of the non-neoplastic disorders and cancer, such as MMP-13 inhibitors in OA [252], MMP-14 inhibitors in RA and cancer [253,254] and MMP-12 inhibitors in COPD [255], all of which have been proven to be effective in animal models. This evidence concerns the gene MMP14 and rheumatoid arthritis.