MMP1 and inflammatory bowel disease: Similarly in human, the expression and proteolytic activity of MMPs, including MMP-1, -2, -3, -7, -9, -10, -12 and -13, have been demonstrated to be elevated in inflamed IBD mucosa or serum of IBD patients [165,166,167,168], and some of these levels corresponded to the severity of the disease or inflammation [169,170,171].