It has been demonstrated both in tissue culture and in murine hepatotoxicity fibrosis models that LSEC can produce a number of inflammatory mediators including pro-inflammaotry cytokines (TNFα, IL-6 and IL-1) and chemokines (CCL2 (MCP-1), CCL3 (MIP1α), CCL4 (Mip1β), CCL5 (Rantes), CXCL1 (KC), CXCL2 (MIP2α))[13,14]. This evidence concerns the gene CCL3 and hepatotoxicity.