We further made the exciting discovery that increasing in vivo Tip60 HAT levels in the Drosophila nervous system under APP induced neurodegenerative conditions rescues AD associated neuronal impairments such as apoptotic neurodegeneration in the central nervous system (CNS) [7], axonal outgrowth [5, 6] and synaptic vesicle transport in motor neurons[2]. Here, KAT5 is linked to Alzheimer disease.