KAT5 and Alzheimer disease: In direct contrast, loss of Tip60 HAT function in the fly nervous system causes gene misregulation and exacerbates such AD associated impaired phenotypes [2, 5–7, 10] Together, our findings demonstrate that Tip60 plays a neuroprotective role in an array of cognition associated neuronal processes that are impaired during the early stages of the AD pathological process.