IRF3 and infection: When comparing control shNT-treated with SNRNP200 KD cells in the context of SeV-mediated infection, regardless of whether or not DDX58 or IRF3 was overexpressed, a significant reduction in the IRF3-p386/IRF3 ratios (from 0.6–0.9 to 0.1–0.2) was observed (Fig 2B).