Kim et al. [21] showed that viral delivery of a chimeric form of Ang-1, cartilage oligomeric matrix protein-Ang-1 (COMP-Ang-1; a soluble and more potent Ang-1 variant than native Ang-1) preserves peritubular capillaries and decreases renal fibrosis and inflammation in a murine unilateral ureteral obstruction (UUO) fibrosis model. The gene discussed is ANGPT1; the disease is renal fibrosis.