ANGPT1 and renal fibrosis: To investigate the effects of inducible tubular-specific Ang-1 upregulation on renal fibrosis, we generated doxycycline (DOX) inducible Ang-1 (TETAng-1) transgenic mice and utilized a reverse tetracycline-controlled transcriptional activator (rtTA) system (Tet-On system) (Fig 1A).