Therefore, CD44 plays an essential role in tumour progression by helping in cancer invasion and metastasis (Jaggupilli and Elkord, 2012).The aim of this study was to elucidate the prognostic impact of the cancer marker CD44 by immunohistochemistry (IHC) in colorectal cancer (CRC) and determine its value as potential biomarker of clinical outcome. The gene discussed is CD44; the disease is cancer.