TNFSF10 and hepatocellular carcinoma: In this study, we generated, and the investigated the single and combination therapy of two oncolytic Ad encoding human TRAIL gene (Ad-ΔB/TRAIL) and oncolytic Ad encoding human IL-12 gene (Ad-ΔB/IL-12) on human hepatocellular carcinoma (human HCC) cell lines and on orthotopic human HCC (Hep3B) model in athymic nude mice.