Selected natural compounds known to suppress the FTO action involved in obesity and lipid metabolism such as (a)Luteolin (Reseda luteola),(b)Quercetin(Emblica officinalis),(c) Capsaicin(Capsicum),(d)Abscisic acid(Abscisin II), (e)Ajoene(Allium sativum), and(f) Diosgenin(Dioscorea villosa) were subjected to comparative docking analysis. This evidence concerns the gene FTO and Obesity.