Among the autosomal located genes that were higher expressed in meningiomas from females were rhotekin 2 (RTKN2), and neuritin 1 (NRN1) and that were lower expressed were fibroblast growth factor 10 (FGF10), mucin 12, cell surface associated (MUC12), Top upstream regulators include the inositol 1,4,5-triphosphate receptor (ITPR) and (E)-2,3′,4,5′-tetramethoxystilbene. The gene discussed is NRN1; the disease is meningioma.