These genes shouldbe considered potential therapeutic targets for HCC in future research.In addition, in BCLC stage 0, VCAM1, HNRNPA2B1, PSMB1, and PSMA5 genes were significant hub genes in theinteractome network, and CBX5, RUVBL1, MORF4L2, and other genes were found to be core genes in the interactome network of unique DEGs in BCLC stage C. These hub genes in BCLC stages 0 and C might be used as biomarkers that complement theBCLC staging system. This evidence concerns the gene CBX5 and hepatocellular carcinoma.