GATA3 and orthostatic hypotension 1: Gata3−/− mice are embryonically lethal from noradrenaline deficiency (Lim et al., 2000) and Gata3−/− rescued embryos display cranial bone development defects, but Gata3+/− mice appear to have no bone developmental abnormalities, which suggests that Gata3 is important for the development of skeletal tissues, but may not be involved in the regulation of bone mineralization gene expression (Lim et al., 2000, Pandolfi et al., 1995).