We then selected five R-DLBCL (OCI-Ly1, OCI-Ly7, WSU-NHL, Farage and Toledo) and P-DLBCL (SU-DHL4) cell lines to determine the anti-proliferative effect of the combination of vorinostat with decitabine by calculating the CI [12]. The gene discussed is RTEL1; the disease is diffuse large B-cell lymphoma.