MKI67 and neoplasm: In cases of intradural soft tissue tumors larger samples of tissue are taken from the vital tumor margins because in addition to classical histological diagnosis and WHO grading, modern pathological examination identifies and quantifies important molecular markers (e.g. Ki67 labeling index, Ip19q, LOH) for adjuvant therapy [64], [65] in order to allow individualized neurooncological multimodal therapy [65].