TNF and stroke disorder: With these results, the existence of a stroke-mediated change in the immune system, i.e. stroke-induced immunodepression which had been reported in many other studies (Chamorro et al. 2007 [31], Haeusler et al. 2008 [27], Klehmet et al. 2009 [7], Urra et al. 2009 [26] and Vogelgesang et al. 2010) [28] could be confirmed, in which alterations in post stroke immune suppression include, but may not be limited to increased serum IL-10 concentrations, decreased serum TNF and decreased TNF-α/ IL-10 ratio.