BCL11A, a transcriptional factor with C2H2 zinc finger DNA-binding motifs, has been extensively studied for its role in hematopoiesis and malignancy8, 9, 10, 11, 12 and as a transcriptional repressor of fetal hemoglobin,13 but its contributions to neurodevelopment are more poorly understood.14, 15, 16, 17 A role for BCL11A in normal human brain function is inferred by the presence of chromosomal microdeletions at 2p15–p16.1 encompassing the gene in individuals with speech sound disorder18 and with more severe ID,19 as well as by a recent association with autism spectrum disorder (ASD).20 This evidence concerns the gene BCL11A and autism spectrum disorder.