Genes disrupted in ID and other neurodevelopmental disorders are enriched for those involved in chromatin remodeling and transcriptional regulation.3, 4 Remarkably, more than 1% of cases are attributed to mutations disrupting genes of the BRG1/BRM-associated factor (BAF) swi/snf chromatin-remodeling complex, suggesting that BAFopathies represent an important recurrent cause of ID.2, 5, 6. The gene discussed is BANF1; the disease is neurodevelopmental disorder.