Given the crucial effects of NO on the pathogenesis and refractoriness of diabetic skin ulcers7, 8 and the critical role of the eNOS/NO pathway in the action mechanism of pro-angiogenic factors13, 14, 15, the up-regulation of eNOS/NO should be a direct and effective strategy for accelerating skin ulcer healing in diabetes. This evidence concerns the gene NOS3 and diabetes mellitus.