VEGFA and atherosclerosis: Many experimental in vitro and animal studies have suggested that angiogenesis inhibitors can suppress plaque neovascularization and atherosclerotic progression6, 17, 18; however, VEGF inhibition was recently reported to disrupt endothelial homeostasis and accelerate atherogenesis in animals19, and anti-VEGF therapy resulted in the acceleration of atherosclerosis in humans, as demonstrated by an increased IMT20.