Consistent with previous studies, our results demonstrated a lower 67-kDa isoform of glutamate decarbox-ylase (GAD67) expression and higher tyrosine hydroxylase (TH) expression in high salt-induced hypertension, indicating that high salt-diet induced sympathyoexcitation and hypertension may result from the imbalance between the excitatory and inhibitory neurotransmitters in the PVN. The gene discussed is TH; the disease is Hypertension.