CD8A and cancer: In order to further distinguish the different cell type populations, other studies have used immunohistochemistry to detect cell surface markers (e.g. CD3, CD8, CD20), demonstrating, for example, that the predictive value of B-cell infiltration is independent of cancer subtype or other clinical factors8, or that CD8+ T-cell infiltration is of good prognosis in basal TNBC5.