CASP3 and neoplasm: In addition, the semi-synthetic Salmonella nanoparticle mimic targets to tumours, may not require access to the cytoplasm for efficacy, and induces functional suppression of P-gp by activation of a caspase-3-dependent degradation pathway (for this efflux pump; see model depicted in Fig. 8, and Hallstrom KN et al.17).