The results of the real time PCR showed that the nasopharyngeal carcinoma CNE-2Z cells expressed ClC-3 and the expression level of ClC-3 mRNA was decreased by (84.7 ± 7.2)% after 48 h treatment with ClC-3 siRNA (n = 3, P < 0.01, vs control, Fig. 1C). The gene discussed is CLCN3; the disease is nasopharyngeal carcinoma.