For example, DRD2 and AKT1 polymorphisms in healthy subjects – implicated in DRD2 signalling – have a selective effect on directed prefrontal-striatal connectivity, while the same polymorphisms alter the dose-response effects of anti-psychotic drugs on cognition in schizophrenia (Tan et al., 2012). The gene discussed is DRD2; the disease is schizophrenia.